Axonal growth and its inhibition
نویسندگان
چکیده
منابع مشابه
Axonal Growth and Targeting
The growth and guidance of axons is an undertaking of both great complexity and great precision, involving processes at a range of length and time scales. Correct axonal guidance involves directing the tips of individual axons and their branches, interactions between branches of a single axon, and interactions between axons of different neurons. In this chapter, we describe examples of models o...
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Because axonal damage and loss are frequent phenomena of multiple sclerosis and other types of neurodegenerative diseases, and because the effects can be devastating clinically, attention has been focused on repair to axons. However, axon regeneration appears to be inhibited via a variety of possible cellular pathways and molecules. In the following article, several of these pathways are examin...
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The growth cone is responsible for axonal growth, where membrane expansion is most likely to occur. Several recent reports have suggested that presynaptic proteins are involved in this process; however, the molecular mechanism details are unclear. We suggest that by cleaving a presynaptic protein syntaxin, which is essential in targeting synaptic vesicles as a target SNAP receptor (t-SNARE), ne...
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Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of the RhoA-Rho kinase pathway. RGMa expression is observed in oligodendrocytes, myelinated fibers, ...
متن کاملOptimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway
Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry-diameter and length-is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin elongation is dynamically regulated by stimulation of YAP (Yes-associated protein) transcription...
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ژورنال
عنوان ژورنال: Eye
سال: 1994
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.1994.53